Pyridinium chloride → HCID 18986570, compound

HRID 2396880Notes

Reaction equation

HRID 2396880 reaction equation
[CH:1]1([CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([C:19]3[CH:24]=[CH:23][C:22]([O:25]C)=[C:21]([O:27]C)[CH:20]=3)[CH2:15][CH2:14]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.Cl.N1C=CC=CC=1>N1C=CC=CC=1>[CH:1]1([CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([C:19]3[CH:24]=[CH:23][C:22]([OH:25])=[C:21]([OH:27])[CH:20]=3)[CH2:15][CH2:14]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 15294772HCID 15294772, compound

Product 1

HCID 18986570HCID 18986570, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 4.1 g of 1-(2-(tetralin-1-yl)ethyl)-4-(3,4-dimethoxyphenyl)piperidine (fumarate, m.p. 154°-156°) 3.2 g of pyridine hydrochloride and 80 ml of pyridine is boiled for 3 hours. It is cooled, evaporated and worked up in the customary manner and gives 1-(2-(tetralin-1-yl)ethyl)-4-(3,4-dihydroxyphenyl)piperidine.

Workup

  1. temperatureIt is cooled
  2. customevaporated

Sources & evidence

ORD record
ord-d3fd54b63f394ce6a5170eb2fd5c451b
Source dataset
uspto-grants-1996_02
Patent number
US05495022

Reaction notes

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