Chloride → 2,3,4,5-Tetrafluoro-6-methylbenzoyl chloride

HRID 2396948Notes

Reaction equation

HRID 2396948 reaction equation
[CH3:1][C:2]1[C:7]([C:8](O)=[O:9])=[C:6]([F:11])[C:5]([F:12])=[C:4]([F:13])[C:3]=1[F:14].[Cl-:15]>>[CH3:1][C:2]1[C:7]([C:8]([Cl:15])=[O:9])=[C:6]([F:11])[C:5]([F:12])=[C:4]([F:13])[C:3]=1[F:14]

Participants

3

Reactant 2

HCID 312ChlorideHCID 129439972,3,4,5-Tetrafluoro-6-methylbenzoic acid

Product 1

HCID 146512562,3,4,5-Tetrafluoro-6-methylbenzoyl chloride

Procedure

To 6-methyl-2,3,4,5-tetrafluorobenzoic acid (5.60 g) is added thiony chloride (9.8 ml) and the mixture is refluxed for 1 hour. After concentrating, 6-methyl-2,3,4,5-tetrafluorobenzoyl chloride (5.20 g) is obtained as a colorless oil, b.p. 82° C./23 mmHg.

Workup

  1. temperaturethe mixture is refluxed for 1 hour
  2. concentrationAfter concentrating

Sources & evidence

ORD record
ord-91ca1c0ea4e94b8e83c5d5e2dab80c09
Source dataset
uspto-grants-1996_02
Patent number
US05495020

Reaction notes

Loading…