p-Toluenesulfonic acid → HCID 15075817, compound

HRID 2396964Notes

Reaction equation

HRID 2396964 reaction equation
[Cl:1][C:2]1[C:3]([F:24])=[C:4]([C:18]([CH3:23])=[C:19]([F:22])[C:20]=1[F:21])[C:5]([CH:7](C(OCC)=O)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:6].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[Cl:1][C:2]1[C:3]([F:24])=[C:4]([C:18]([CH3:23])=[C:19]([F:22])[C:20]=1[F:21])[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:6]

Participants

3

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 54251065HCID 54251065, compound

Product 1

HCID 15075817HCID 15075817, compoundYield 116.7%

Procedure

Employing diethyl 3-chloro-2,4,5-trifluoro-6-methylbenzoylmalonate (320 mg) and p-toluenesulfonic acid (3 mg), the procedure of Reference Example 19 is repeated to give ethyl 3-chloro-2,4,5-trifluoro-6-methylbenzoylacetate (300 mg), as brown oil.

Sources & evidence

ORD record
ord-2515f0d8bc6a4e1c8deb3dae4a7a17bc
Source dataset
uspto-grants-1996_02
Patent number
US05495020

Reaction notes

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