Imidazo(4,5-b)pyridine → HCID 22859140, compound

HRID 2396993Notes

Reaction equation

HRID 2396993 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[NH:15]1[C:23]2[C:18](=[N:19][CH:20]=[CH:21][CH:22]=2)[N:17]=[CH:16]1.FC1C=C(F)C=CC=1[C@]1([C@H](N2C3=NC=CC=C3N=C2)C)CO1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@H:12]([N:15]2[C:23]3[C:18](=[N:19][CH:20]=[CH:21][CH:22]=3)[N:17]=[CH:16]2)[CH3:13])[CH2:11][O:10]1

Participants

4

Reactant 3

HCID 67504Imidazo(4,5-b)pyridineHCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanolHCID 22859141HCID 22859141, compound

Product 1

HCID 22859140HCID 22859140, compoundYield 22.7%

Procedure

Using (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol (981 mg) and 1H-imidazo[4,5-b]pyridine (472 mg), (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-(3H-3-imidazo[4,5-b]pyridyl)ethyl]oxirane (501 mg) and (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-(1H-1-imidazo[4,5-b]pyridyl)ethyl]oxirane (271 mg) were obtained by the same way as in Reference Example 2.

Sources & evidence

ORD record
ord-cd7f84d56ea64516ad8c9ad910584751
Source dataset
uspto-grants-1996_02
Patent number
US05495024

Reaction notes

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