Hydrochloric Acid → Bis(2-chloroethyl)carbamoyl chloride

A solution in dry benzene of 82 g. of bis-(β-chloroethyl)-amine freshly liberated from its hydrochloride is added gradually to a solution of 36 g. of carbonyl chloride in benzene at a temperature below 10° C. The mixture is mechanically stirred for three hours, the precipitate of bis-(β-chloroethyl)-amine hydrochloride is removed by filtration, and the benzene is distilled off on a water bath. The residue is distilled in vacuo, and the N-chloroformyl-bis-(β-chloroethyl)-amine is obtained as a pale yellow oil with a B.P. of 114-116° C./1 mm. Hg.

1. additionis added gradually to a solution of 36 g
2. customat a temperature below 10° C
3. customthe precipitate of bis-(β-chloroethyl)-amine hydrochloride is removed by filtration
4. distillationthe benzene is distilled off on a water bath
5. distillationThe residue is distilled in vacuo

ORD record

ord-6602ee58881b4db3a221b90a5454516d

Source dataset

uspto-grants-1977_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

USRE029199