2-ACETAMIDO-6-METHYLPYRIDINE → N-Ethyl-6-methylpyridin-2-amine

HRID 2397208Notes

Reaction equation

HRID 2397208 reaction equation
[C:1]([NH:4][C:5]1[N:10]=[C:9]([CH3:11])[CH:8]=[CH:7][CH:6]=1)(=O)[CH3:2].B#B>>[CH2:1]([NH:4][C:5]1[N:10]=[C:9]([CH3:11])[CH:8]=[CH:7][CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 2204862-ACETAMIDO-6-METHYLPYRIDINEHCID 6328200Diboron

Product 1

HCID 3016051N-Ethyl-6-methylpyridin-2-amine

Procedure

In a process for producing 6-ethylamino-2-picoline by reduction of 6-acetamido-2-picoline, the improvement which comprises reacting 6-acetamido-2-picoline with diborane in an inert non-polar solvent at about 0° to 70° C. to produce 6-ethylamino-2-picoline and using a low boiling petroleum solvent to separate the soluble 6-ethylamino-2-picoline from the insoluble 6-acetamido-2-picoline.

Workup

  1. customat about 0° to 70° C.

Sources & evidence

ORD record
ord-23bd2b84318a41e5a62799fab7040fbb
Source dataset
uspto-grants-1977_05
Patent number
US04021437

Reaction notes

Loading…