Ethylenediamine → HCID 21437376, compound

HRID 2397220Notes

Reaction equation

HRID 2397220 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[O:16][C:15]([C:17](=[NH:21])OCC)=[CH:14][CH:13]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11].[CH2:22](N)[CH2:23][NH2:24]>C(O)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[O:16][C:15]([C:17]3[NH:21][CH2:22][CH2:23][N:24]=3)=[CH:14][CH:13]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 3301EthylenediamineHCID 21437378HCID 21437378, compound

Product 1

HCID 21437376HCID 21437376, compoundYield 66.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 51 g (0.16 mole) of ethyl 5-(3,4-dimethoxyphenyl)-2-furimidate hydrochloride, 11 g (0.18 mole) of ethylenediamine, and 850 ml of absolute ethanol was refluxed for 5 hrs and then kept overnight at room temperature. The solid was recrystallized from acetic acid, washed with ether, and air dried to yield 33 g (65%) of 2-[5-(3,4-dimethoxyphenyl)-2-furyl]imidazoline hydrochloride. An analytical sample was prepared by recrystallizing a sample from methanol and drying in the vacuum pistol at the temperature of refluxing CHCl3, m.p. 291°-293°.

Workup

  1. temperaturewas refluxed for 5 hrs
  2. customThe solid was recrystallized from acetic acid
  3. washwashed with ether, and air
  4. customdried

Sources & evidence

ORD record
ord-1053095ed29748cf8b10119bd2c4c70e
Source dataset
uspto-grants-1977_05
Patent number
US04021444

Reaction notes

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