Potassium Iodide → HCID 21437359, compound

HRID 2397312Notes

Reaction equation

HRID 2397312 reaction equation
[I-].[K+].[N+:3]([C:6]1[CH:7]=[CH:8][C:9]2[N:15]3[C:16]([CH2:19]Cl)=[N:17][N:18]=[C:14]3[CH2:13][N:12]=[C:11]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[Cl:27])[C:10]=2[CH:28]=1)([O-:5])=[O:4].[CH:29]1([NH2:32])[CH2:31][CH2:30]1>O1CCCC1>[N+:3]([C:6]1[CH:7]=[CH:8][C:9]2[N:15]3[C:16]([CH2:19][NH:32][CH:29]4[CH2:31][CH2:30]4)=[N:17][N:18]=[C:14]3[CH2:13][N:12]=[C:11]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[Cl:27])[C:10]=2[CH:28]=1)([O-:5])=[O:4]

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 69828CyclopropylamineHCID 233374678-nitro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Product 1

HCID 21437359HCID 21437359, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 1, potassium iodide and 8-nitro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in tetrahydrofuran is treated with cyclopropylamine to give 8-nitro 1-[(cyclopropylamino)methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine.

Sources & evidence

ORD record
ord-8f4d0eb69aa34f76b2ff222badd84385
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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