Potassium Iodide → Benzodiazepine

HRID 2397313Notes

Reaction equation

HRID 2397313 reaction equation
[I-].[K+].[N+](C1C=C[C:9]2[N:15]3C(CCl)=NN=C3CN=[C:11]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3Cl)[C:10]=2C=1)([O-])=O.C[NH:30]C1CC1>O1CCCC1>[NH:30]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[CH:11]=[CH:10][CH:9]=[N:15]1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 11029756N-MethylcyclopropanamineHCID 233374678-nitro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Product 1

HCID 134664Benzodiazepine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 2, potassium iodide and 8-nitro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in tetrahydrofuran are treated with methylcyclopropylamine to give 8-nitro-1-[(cyclopropylmethylamino)methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-]1,4]benzodiazepine.

Sources & evidence

ORD record
ord-67ba7fc619534de3aa356313d79962a9
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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