Potassium Iodide → 8-(trifluoromethyl)-1-[(cyclopropylmethylamino)methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

HRID 2397316Notes

Reaction equation

HRID 2397316 reaction equation
[I-].[K+].[F:3][C:4]([F:29])([F:28])[C:5]1[CH:6]=[CH:7][C:8]2[N:14]3[C:15]([CH2:18]Cl)=[N:16][N:17]=[C:13]3[CH2:12][N:11]=[C:10]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])[C:9]=2[CH:27]=1.C[NH:31]C1CC1.O1[CH2:39][CH2:38][CH2:37][CH2:36]1>>[F:3][C:4]([F:29])([F:28])[C:5]1[CH:6]=[CH:7][C:8]2[N:14]3[C:15]([CH2:18][NH:31][CH2:36][CH:37]4[CH2:39][CH2:38]4)=[N:16][N:17]=[C:13]3[CH2:12][N:11]=[C:10]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])[C:9]=2[CH:27]=1

Participants

5

Reactant 4

HCID 4875Potassium IodideHCID 8028TetrahydrofuranHCID 11029756N-MethylcyclopropanamineHCID 213307808-(trifluoromethyl)-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Product 1

HCID 214372888-(trifluoromethyl)-1-[(cyclopropylmethylamino)methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Procedure

In the manner given in Example 2, potassium iodide and 8-(trifluoromethyl)-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in tetrahydrofuran is treated with methylcyclopropylamine to give 8-(trifluoromethyl)-1-[(cyclopropylmethylamino)methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-172bdc5146394fd6a452d4ab1a0bf87f
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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