Potassium Iodide → HCID 21437293, compound

HRID 2397317Notes

Reaction equation

HRID 2397317 reaction equation
[I-].[K+].[F:3][C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17]Cl)=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[Cl:25])[C:8]=2[CH:26]=1.[CH:27]1([NH2:30])[CH2:29][CH2:28]1>O1CCCC1>[F:3][C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17][NH:30][CH:27]4[CH2:29][CH2:28]4)=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[Cl:25])[C:8]=2[CH:26]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 69828CyclopropylamineHCID 21437262HCID 21437262, compound

Product 1

HCID 21437293HCID 21437293, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 1, potassium iodide and 8-fluoro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in tetrahydrofuran is treated with cyclopropylamine to give 8-fluoro-1-[(cyclopropylamino)methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine.

Sources & evidence

ORD record
ord-cda985bfbeed4f368c18b6574e22846c
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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