Potassium Iodide → HCID 21437253, compound

HRID 2397323Notes

Reaction equation

HRID 2397323 reaction equation
[I-].[K+].[Br:3][C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17]Cl)=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:8]=2[CH:25]=1.[CH:26]1([NH2:29])[CH2:28][CH2:27]1>O1CCCC1>[Br:3][C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17][NH:29][CH:26]4[CH2:28][CH2:27]4)=[N:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:8]=2[CH:25]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 69828CyclopropylamineHCID 20291841HCID 20291841, compound

Product 1

HCID 21437253HCID 21437253, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 1, potassium iodide and 8-bromo-1-(chloromethyl)-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine in tetrahydrofuran is treated with cyclopropylamine to give 8-bromo-1-[(cyclopropylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Sources & evidence

ORD record
ord-757b7e3033e6447badbc86443d69ea78
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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