Potassium Iodide → HCID 21437267, compound

HRID 2397326Notes

Reaction equation

HRID 2397326 reaction equation
[I-].[K+].[CH3:3][S:4][C:5]1[CH:6]=[CH:7][C:8]2[N:14]3[C:15]([CH2:18]Cl)=[N:16][N:17]=[C:13]3[CH2:12][N:11]=[C:10]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:9]=2[CH:26]=1.C(N[CH:31]1[CH2:33][CH2:32]1)CC>O1CCCC1>[CH3:3][S:4][C:5]1[CH:6]=[CH:7][C:8]2[N:14]3[C:15]([CH2:18][NH:11][CH2:10][CH2:9][CH2:8][CH:31]4[CH2:32][CH2:33]4)=[N:16][N:17]=[C:13]3[CH2:12][N:11]=[C:10]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:9]=2[CH:26]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 12094059N-propylcyclopropanamineHCID 203611608-(methylthio)-1-(chloromethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Product 1

HCID 21437267HCID 21437267, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 2, potassium iodide and 8-(methylthio)-1-(chloromethyl)-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine in tetrahydrofuran is treated with propylcyclopropylamine to give 8-(methylthio)-1-[(cyclopropylpropylamino)methyl]-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-17569e611b8344e98b52237270f42a65
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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