Potassium Iodide → HCID 21437338, compound

HRID 2397327Notes

Reaction equation

HRID 2397327 reaction equation
[I-].[K+].Cl[CH2:4][C:5]1[N:9]2[C:10]3[CH:25]=[CH:24][CH:23]=[CH:22][C:11]=3[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])=[N:13][CH2:14][C:8]2=[N:7][N:6]=1.[CH:26]1([NH2:29])[CH2:28][CH2:27]1>O1CCCC1>[CH:26]1([NH:29][CH2:4][C:5]2[N:9]3[C:10]4[CH:25]=[CH:24][CH:23]=[CH:22][C:11]=4[C:12]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=4[Cl:21])=[N:13][CH2:14][C:8]3=[N:7][N:6]=2)[CH2:28][CH2:27]1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 69828CyclopropylamineHCID 12612349HCID 12612349, compound

Product 1

HCID 21437338HCID 21437338, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 1, potassium iodide and 1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine in tetrahydrofuran is treated with cyclopropylamine to give 1-[(cyclopropylamino)-methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine.

Sources & evidence

ORD record
ord-07d61b8ea2a4433686ccc37ca2d8fca8
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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