Potassium Iodide → HCID 21437290, compound

HRID 2397328Notes

Reaction equation

HRID 2397328 reaction equation
[I-].[K+].Cl[CH2:4][C:5]1[N:9]2[C:10]3[CH:25]=[CH:24][CH:23]=[CH:22][C:11]=3[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])=[N:13][CH2:14][C:8]2=[N:7][N:6]=1.C[NH:27]C1CC1.O1[CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH:34]1([CH2:35][NH:27][CH2:4][C:5]2[N:9]3[C:10]4[CH:25]=[CH:24][CH:23]=[CH:22][C:11]=4[C:12]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=4[Cl:21])=[N:13][CH2:14][C:8]3=[N:7][N:6]=2)[CH2:32][CH2:33]1

Participants

5

Reactant 4

HCID 4875Potassium IodideHCID 8028TetrahydrofuranHCID 11029756N-MethylcyclopropanamineHCID 12612349HCID 12612349, compound

Product 1

HCID 21437290HCID 21437290, compound

Procedure

In the manner given in Example 2, potassium iodide and 1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine in tetrahydrofuran is treated with methylcyclopropylamine to give 1-[(cyclopropylmethylamino)methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine.

Sources & evidence

ORD record
ord-30b5aa48ed7941f1b803d8327046853d
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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