Potassium Iodide → HCID 21437290, compound

HRID 2397329Notes

Reaction equation

HRID 2397329 reaction equation
[OH-].[K+].Cl.[CH:4]1([CH2:7][NH2:8])[CH2:6][CH2:5]1.Cl[CH2:10][C:11]1[N:15]2[C:16]3[CH:31]=[CH:30][CH:29]=[CH:28][C:17]=3[C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[Cl:27])=[N:19][CH2:20][C:14]2=[N:13][N:12]=1.[I-].[K+]>O1CCCC1>[CH:4]1([CH2:7][NH:8][CH2:10][C:11]2[N:15]3[C:16]4[CH:31]=[CH:30][CH:29]=[CH:28][C:17]=4[C:18]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[Cl:27])=[N:19][CH2:20][C:14]3=[N:13][N:12]=2)[CH2:6][CH2:5]1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 14797Potassium HydroxideHCID 81671(Cyclopropylmethyl)ammonium chlorideHCID 12612349HCID 12612349, compound

Product 1

HCID 21437290HCID 21437290, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 3, a solution of potassium hydroxide and (cyclopropylmethyl)amine hydrochloride is treated with a solution of 1-(chloromethyl)-6-(o-chlorophenyl)-4-H-s-triazolo[4,3-a][1,4]benzodiazepine and potassium iodide in tetrahydrofuran to give 1-[[(cyclopropylmethyl)amino]methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-5a8227f262164b9195de87dc0c989f57
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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