Potassium Iodide → HCID 21437335, compound

HRID 2397330Notes

Reaction equation

HRID 2397330 reaction equation
[I-].[K+].[CH2:3]([S:5][C:6]1[C:11]2[C:12]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=3)=[N:13][CH2:14][C:15]3[N:16]([C:17]([CH2:20]Cl)=[N:18][N:19]=3)[C:10]=2[CH:9]=[CH:8][CH:7]=1)[CH3:4].[CH:29]1([NH2:32])[CH2:31][CH2:30]1>O1CCCC1>[CH2:3]([S:5][C:6]1[C:11]2[C:12]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=3)=[N:13][CH2:14][C:15]3[N:16]([C:17]([CH2:20][NH:32][CH:29]4[CH2:31][CH2:30]4)=[N:18][N:19]=3)[C:10]=2[CH:9]=[CH:8][CH:7]=1)[CH3:4]

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 69828CyclopropylamineHCID 21437245HCID 21437245, compound

Product 1

HCID 21437335HCID 21437335, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 1, a potassium iodide and 7-(ethylthio)-1-(chloromethyl)-6-(m-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in tetrahydrofuran is treated with cyclopropylamine to give 7-(ethylthio)-1-[(cyclopropylamino)methyl]-6-(m-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-6437b309ea33488cbf0cb3263c6b35f7
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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