Potassium Iodide → HCID 21437243, compound

HRID 2397331Notes

Reaction equation

HRID 2397331 reaction equation
[I-].[K+].[CH2:3]([S:5][C:6]1[C:11]2[C:12]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=3)=[N:13][CH2:14][C:15]3[N:16]([C:17]([CH2:20]Cl)=[N:18][N:19]=3)[C:10]=2[CH:9]=[CH:8][CH:7]=1)[CH3:4].C[NH:30]C1CC1.O1[CH2:38][CH2:37][CH2:36][CH2:35]1>>[CH2:3]([S:5][C:6]1[C:11]2[C:12]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=3)=[N:13][CH2:14][C:15]3[N:16]([C:17]([CH2:20][NH:30][CH2:35][CH:36]4[CH2:38][CH2:37]4)=[N:18][N:19]=3)[C:10]=2[CH:9]=[CH:8][CH:7]=1)[CH3:4]

Participants

5

Reactant 4

HCID 4875Potassium IodideHCID 8028TetrahydrofuranHCID 11029756N-MethylcyclopropanamineHCID 21437245HCID 21437245, compound

Product 1

HCID 21437243HCID 21437243, compound

Procedure

In the manner given in Example 2, potassium iodide and 7-(ethylthio)-1-(chloromethyl)-6-(m-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in tetrahydrofuran is treated with methylcyclopropylamine to give 7-(ethylthio)-1-[(cyclopropylmethylamino)methyl]-6-(m-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-0dc3d6492f994fb4abc4d8d9a0364a7a
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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