Potassium Iodide → HCID 68125040, compound

HRID 2397347Notes

Reaction equation

HRID 2397347 reaction equation
Cl[CH2:2][C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][CH:21]=[CH:20][C:9]=3[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])=[N:11][CH2:12][C:6]2=[N:5][N:4]=1.[I-].[K+].[CH3:26][CH:27]=[CH:28][CH2:29][NH2:30]>O1CCCC1>[CH2:28]([CH2:29][NH:30][CH2:2][C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][CH:21]=[CH:20][C:9]=3[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])=[N:11][CH2:12][C:6]2=[N:5][N:4]=1)[CH:27]=[CH2:26]

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 304472-Buten-1-amineHCID 12612349HCID 12612349, compound

Product 1

HCID 68125040HCID 68125040, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 32, 1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine, potassium iodide, and methylallylamine in tetrahydrofuran are reacted to give 1-[(allylmethylamino)methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-8c7d18ce8d2045cc85a8ccb440e292f2
Source dataset
uspto-grants-1977_05
Patent number
US04021441

Reaction notes

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