Perchloric Acid → 4-(4'-Fluoro-4-biphenylyl)-butyric acid

HRID 2397367Notes

Reaction equation

HRID 2397367 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=O)[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl(O)(=O)(=O)=O>C(O)(=O)C.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 24247Perchloric AcidHCID 107308704-(4'-Fluoro-4-biphenylyl)-4-oxo-butyric acid

Product 1

HCID 108487954-(4'-Fluoro-4-biphenylyl)-butyric acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

5.0 gm (0.018 mol) of 4-(4'-fluoro-4-biphenylyl)-4-oxo-butyric acid were hydrogenated in 50 ml of acetic acid under addition of 1.5 ml of perchloric acid in the presence of 1.5 gm of palladium/barium sulfate (5%) as catalyst at room temperature and at a pressure of 5 atmospheres in a Parr-autoclave.

Sources & evidence

ORD record
ord-4845e8c4588644b88192696b3fc5e304
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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