Cyclohexylamine → HCID 21437957, compound

HRID 2397370Notes

Reaction equation

HRID 2397370 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15](=O)[CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:11][CH:10]=1.C1(N)CCCCC1>C(OCC)(=O)C.CO>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 21437918HCID 21437918, compound

Product 1

HCID 21437957HCID 21437957, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 21584119Ethylacetate methanolSolvent

Procedure

Prepared analogous to Example 1 from 4-(2'-chloro-4'-fluoro-4-biphenylyl)-4-oxo-butyric acid. Yield: 84% of theory; m.p. 81°-82° C. (petroleum ether-cyclohexane). Melting point of the cyclohexylamine salt: 148°-149° C. (from ethyl acetate/methanol 9:1).

Sources & evidence

ORD record
ord-d03cf958fdc542b49f9004433fa2b166
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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