Cyclohexylamine → 4-(4'-Fluoro-4-biphenylyl)-4-hydroxy-butyric acid

HRID 2397392Notes

Reaction equation

HRID 2397392 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:20])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.C1(N)CCCCC1>O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH:14]([OH:20])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 107308704-(4'-Fluoro-4-biphenylyl)-4-oxo-butyric acid

Product 1

HCID 214379434-(4'-Fluoro-4-biphenylyl)-4-hydroxy-butyric acidYield 54%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared analogous to Example 25 from 4-(4'-fluoro-4-biphenylyl)-4-oxo-butyric acid. Melting point of the cyclohexylamine salt: 175°-177° C. (from water). Yield 54% of theory.

Sources & evidence

ORD record
ord-ade0dce29af44958a8d898ad79f83a23
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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