反应详情

A mixture of 9 gm (0.03 mol) of ethyl 4-(2'-fluoro-4-biphenylyl)-4-oxo-butyrate, 150 ml of absolute isopropanol and 6.2 gm (0.03 mol) of freshly distilled aluminum isopropylate was refluxed on a boiling water bath, while condensing the vapors in a descending condenser, until no more acetone was detectable in the distillate. After removing the solvent in vacuo, the residue was covered with ether, the mixture was acidified with dilute hydrochloric acid, and the ethereal phase was separated, washed with sodium bicarbonate and water. After distilling off the solvent, the solid residue was recrystallized from cyclohexane, to yield 6 gm (78% of theory) of colorless γ-(2'-fluoro-4-biphenylyl)-γ-butyrolactone, m.p. 74°-75° C.

1. temperaturewas refluxed on a boiling water bath, while condensing the vapors in a descending condenser
2. customAfter removing the solvent in vacuo
3. customthe ethereal phase was separated
4. washwashed with sodium bicarbonate and water
5. distillationAfter distilling off the solvent
6. customthe solid residue was recrystallized from cyclohexane