Water → HCID 21437931, compound

HRID 2397412Notes

Reaction equation

HRID 2397412 reaction equation
N1CCOCC1.[F:7][C:8]1[CH:9]=[C:10]([C:15]2[CH:20]=[CH:19][C:18]([CH:21]([OH:27])/[CH:22]=[CH:23]/[C:24]([OH:26])=[O:25])=[CH:17][CH:16]=2)[CH:11]=[CH:12][C:13]=1[F:14].C1(N)CCCCC1.O>CO>[F:7][C:8]1[CH:9]=[C:10]([C:15]2[CH:16]=[CH:17][C:18]([CH:21]([OH:27])[CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[CH:19][CH:20]=2)[CH:11]=[CH:12][C:13]=1[F:14]

Participants

6

Reactant 4

HCID 962WaterHCID 7965CyclohexylamineHCID 8083MorpholineHCID 21437981HCID 21437981, compound

Product 1

HCID 21437931HCID 21437931, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared analogous to Example 46 from the morpholine salt of 4-(3',4'-difluoro-4-biphenylyl)-4-hydroxy-crotonic acid in methanol. Melting point of the cyclohexylamine salt: 170°-171° C. (from water). Yield: 44% of theory.

Sources & evidence

ORD record
ord-180983b024eb4c4fb2ae03b04c68ee35
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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