4-Nitrobenzaldehyde → HCID 70632235, compound

HRID 2397475Notes

Reaction equation

HRID 2397475 reaction equation
[NH:1]([C:3]([C@@H:5]([C@@H:14]([C@@H:23]([CH2:25][O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)O)[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4])[NH2:2].[N+:34]([C:37]1[CH:44]=[CH:43][C:40]([CH:41]=O)=[CH:39][CH:38]=1)([O-:36])=[O:35]>CO>[CH2:7]([O:6][C@@H:5]1[C@H:14]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C@@H:23]([CH2:25][O:26][CH2:27][C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[O:4][CH:3]1[NH:1][N:2]=[CH:41][C:40]1[CH:43]=[CH:44][C:37]([N+:34]([O-:36])=[O:35])=[CH:38][CH:39]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 5414-NitrobenzaldehydeHCID 53641074HCID 53641074, compound

Product 1

HCID 70632235HCID 70632235, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.4 g (5.55 mmoles) of 1-hydrazino-2,3,5-tri-O-benzyl-D-ribose are dissolved in 10 ml of absolute methanol. 0.84 g (5.55 mmoles) of p-nitrobenzaldehyde (dissolved in 8 ml of absolute methanol) are added to the solution. Stirring is carried out at room temperature and after approximately 5 minutes a yellow flaky precipitate appears. After 24 hours the precipitate is drawn off by suction and dried. Yield: 2.4 g (76 %). Melting point: 93° C. (from methanol).

Workup

  1. waitAfter 24 hours the precipitate is drawn off by suction
  2. customdried

Sources & evidence

ORD record
ord-94420a5e712c4603a8fd56c59eea8401
Source dataset
uspto-grants-1977_05
Patent number
US04021542

Reaction notes

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