Hydrazine hydrate (1:1) → HCID 54319379, compound

HRID 2397478Notes

Reaction equation

HRID 2397478 reaction equation
[CH3:1][O:2][C@H:3]([C@@H:6]([C@@H:9]([CH2:11][O:12][CH3:13])[OH:10])[O:7][CH3:8])[CH:4]=[O:5].O.[NH2:15][NH2:16]>CO>[NH:15]([C:4]([C@@H:3]([C@@H:6]([C@@H:9]([CH2:11][O:12][CH3:13])[OH:10])[O:7][CH3:8])[O:2][CH3:1])=[O:5])[NH2:16]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)2×HCID 53940507HCID 53940507, compound

Product 1

HCID 54319379HCID 54319379, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

1.7 g (8.5 mmoles) of 2,3,5-tri-O-methyl-D-ribose are dissolved in 5 ml of absolute methanol. While stirring, 4.25 g (85 mmoles) of 100% hydrazine hydrate (dissolved in 5 ml of absolute methanol) are added. As a result slight heating occurs. Stirring is carried out for 2 days of room temperature. Following this methanol and superfluous hydrazine hydrate are removed in a rotary evaporator at room temperature (oil pump vacuum). Following this drying is carried out for one day under oil pump vacuum. A colorless oil is obtained. Yield: 1.6 g (92 %).

Workup

  1. temperatureAs a result slight heating
  2. stirringStirring
  3. customare removed in a rotary evaporator at room temperature (oil pump vacuum)
  4. waitis carried out for one day under oil pump vacuum
  5. customA colorless oil is obtained

Sources & evidence

ORD record
ord-dd8a47f2ed8e407390503f5bd7e3bdb5
Source dataset
uspto-grants-1977_05
Patent number
US04021542

Reaction notes

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