反应详情

A mixture of 1-ethynylcyclohexylamine (6 g, 48.7 mmol) and 1,3-propane sultone (6.55 g, 53.6 mmol) in THF (35 mL) was heated at reflux for 2 hours (thick paste). The mixture was cooled to room temperature. The solid was collected by filtration, rinsed with THF (3×5 mL), air-dried 15 minutes (7.3 g). The solid was suspended in ethanol (30 mL) and the suspension was heated at reflux for 1 hour. The mixture was then cooled to room temperature and the solid was collected by suction filtration, rinsed with ethanol (2×5 mL), air-dried for 10 min, and further dried in a vacuum oven at 60° C. overnight (crop1, 7.10 g). The combined mother liquors were stirred overnight at room temperature. There was a lot of solid. The solid was collected by filtration, rinsed with acetone (3×5 mL), air-dried for 30 minutes, and then suspended in ethanol (12 mL). The suspension was heated at reflux for 1 hour. The mixture was then cooled to room temperature and the solid was collected by suction filtration, rinsed with ethanol (2×5 mL), air-dried for 2 minutes, and further dried in a vacuum oven at 60° C. overnight (crop 2: 1.85 g). Compound DX was obtained as a fine white solid (two crops in total 8.95 g, 75% yield). 1H NMR (500 MHz, D2O) δ 0.95-1.05 (m, 1H), 1.38-1.54 (m, 5H), 1.60-1.64 (m, 2H), 1.94 (qt, J=7.8 Hz, 2H), 2.85 (t, J=7.3 Hz, 2H), 3.01 (s, 1H), 3.22 (t, J=7.8 Hz, 2H). 13C NMR (125 MHz, D2O) δ 21.8, 22.3, 24.2, 34.4, 40.9, 48.0, 59.2, 78.6, 79.3. ES-MS 243.0 (M−1).

1. temperaturewas heated
2. temperatureat reflux for 2 hours (thick paste)
3. filtrationThe solid was collected by filtration
4. washrinsed with THF (3×5 mL)
5. customair-dried 15 minutes (7.3 g)
6. temperaturethe suspension was heated
7. temperatureat reflux for 1 hour
8. temperatureThe mixture was then cooled to room temperature
9. filtrationthe solid was collected by suction filtration
10. washrinsed with ethanol (2×5 mL)
11. customair-dried for 10 min
12. customfurther dried in a vacuum oven at 60° C. overnight (crop1, 7.10 g)
13. filtrationThe solid was collected by filtration
14. washrinsed with acetone (3×5 mL)
15. customair-dried for 30 minutes
16. temperatureThe suspension was heated
17. temperatureat reflux for 1 hour
18. temperatureThe mixture was then cooled to room temperature
19. filtrationthe solid was collected by suction filtration
20. washrinsed with ethanol (2×5 mL)
21. customair-dried for 2 minutes
22. customfurther dried in a vacuum oven at 60° C. overnight (crop 2: 1.85 g)
23. customCompound DX was obtained as a fine white solid (two crops in total 8.95 g, 75% yield)