1-Methylpiperazine → HCID 53786027, compound

HRID 2397566Notes

Reaction equation

C[N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH2:8]([O:10][C:11]([C:13]1[C:14]([CH3:29])=[N:15][C:16]([N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)=C([N+]([O-])=O)C=1Cl)=[O:12])[CH3:9]>>[CH2:8]([O:10][C:11]([C:13]1[C:3]2[C:4](=[N:5][CH:6]=[CH:7][N:2]=2)[C:16]([N:23]2[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]2)=[N:15][C:14]=1[CH3:29])=[O:12])[CH3:9]

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 53886039HCID 53886039, compound

Product 1

HCID 53786027HCID 53786027, compound

Procedure

By substituting piperidine for N-methylpiperazine in Example 1 b and the resulting 4-chloro-2-methyl-6-(1-piperidinyl)-5-nitropyridine-3-carboxylic acid ethyl ester is processed according to the procedure in Example 1 c-e, 7-methyl-5-(1-piperidinyl)pyrido[3,4-b]pyrazine-8-carboxylic acid ethyl ester is obtained, m.p. 73°-74° (petroleum ether).

Sources & evidence

ORD record: ord-f66da1b1367e48fab4e7bbe390473332
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04022779

Reaction notes

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