1-Methylpiperazine → HCID 54493330, compound

HRID 2397567Notes

Reaction equation

C[N:2]1CCN[CH2:4][CH2:3]1.[CH2:8]([O:10][C:11]([C:13]1[C:14]([CH3:35])=[N:15][C:16]([N:23]2[CH2:28][CH2:27][N:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:25][CH2:24]2)=[C:17]([N+:20]([O-])=O)[C:18]=1Cl)=[O:12])[CH3:9]>>[CH2:8]([O:10][C:11]([C:13]1[C:18]2[C:17](=[N:20][CH:4]=[CH:3][N:2]=2)[C:16]([N:23]2[CH2:28][CH2:27][N:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:25][CH2:24]2)=[N:15][C:14]=1[CH3:35])=[O:12])[CH3:9]

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 54357563HCID 54357563, compound

Product 1

HCID 54493330HCID 54493330, compound

Procedure

By substituting N-phenylpiperazine for N-methylpiperazine in Example 1 b and the resulting 4-chloro-2-methyl-6-(4-phenyl-1-piperazinyl)-5-nitropyridine-3-carboxylic acid ethyl ester is processed as described in Example 1 c-e, 7-methyl-5-(4-phenyl-1piperazinyl)pyrido[3,4-b]pyrazine-8-carboxylic acid ethyl ester is formed, m.p. 85°-87° (ligroin).

Sources & evidence

ORD record: ord-0a9258bc840d4309b340d9a820844a66
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04022779

Reaction notes

Loading…