Morpholine → HCID 12781929, compound

HRID 2397595Notes

Reaction equation

HRID 2397595 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([C:12]3[S:13][CH:14]=[CH:15][C:16]=3[CH2:17]Br)=[N:9][C:8]=2[CH:19]=1)([O-:3])=[O:2].[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>C1C=CC=CC=1>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([C:12]3[S:13][CH:14]=[CH:15][C:16]=3[CH2:17][N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[N:9][C:8]=2[CH:19]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 12781926HCID 12781926, compound

Product 1

HCID 12781929HCID 12781929, compoundYield 78.8%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 5-nitro-2-(3-bromomethyl-2-thienyl)-benzoxazole (5.0 g, 0.0147 mole) and morpholine (2.6 g, 0.03 mole) in 200 ml of benzene is refluxed for 24 hours. The precipitated morpholine hydrobromide is removed by filtration and the benzene evaporated under vacuum yielding 4.0 g of solid. Crystallization from ethanol yields 3.4 g of product, melting point 143°-145° C.

Workup

  1. temperatureis refluxed for 24 hours
  2. customThe precipitated morpholine hydrobromide is removed by filtration
  3. customthe benzene evaporated under vacuum

Sources & evidence

ORD record
ord-31097fcc04a14eccaf7b249439586afa
Source dataset
uspto-grants-1977_05
Patent number
US04022781

Reaction notes

Loading…