Hydrochloric Acid → HCID 21436090, compound

HRID 2397636Notes

Reaction equation

HRID 2397636 reaction equation
F[C:2]1[CH:13]=[CH:12][C:5]([C:6]([CH2:8][CH2:9][CH2:10]I)=[O:7])=[CH:4][CH:3]=1.C(CCCI)(=O)C1C=CC=CC=1.[C:26]1([C:32]2([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[ClH:44]>>[ClH:44].[C:6]([CH2:8][CH2:9][CH2:10][N:35]1[CH2:36][CH2:37][C:32]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[CH2:33][CH2:34]1)(=[O:7])[C:5]1[CH:12]=[CH:13][CH:2]=[CH:3][CH:4]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 28232394,4-Diphenylpiperidine2×HCID 30162324'-Fluoro-4-iodobutyrophenoneHCID 110869514-Iodo-1-phenylbutan-1-one2×

Product 1

HCID 21436090HCID 21436090, compound

Procedure

When proceeding as described in Example 28, but replacing 3-(p-fluorobenzoyl)propyl iodide (used as the one reactant in said example) by 3-benzoylpropyl iodide and reacting 27.4 g. of said 3-benzoylpropyl iodide with 24.4 g. of 4,4-diphenylpiperidine, on addition of hydrochloric acid to the etheric solution of the diphenylpiperidine base 19.5 g. of 1-(3-benzoylpropyl)-4,4-diphenylpiperidine hydrochloride are obtained. On recrystallization from ethanol, the hydrochloride melts at 200° C.

Sources & evidence

ORD record
ord-3cba50d67ae140a896c7f43895265fc1
Source dataset
uspto-grants-1977_05
Patent number
US04022786

Reaction notes

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