Hydrazine hydrate (1:1) → HCID 21431643, compound

HRID 2397649Notes

Reaction equation

HRID 2397649 reaction equation
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]2[C:6](=O)[C:7](=[CH:17][N:18](C)C)[CH2:8][N:9]=[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.O.[NH2:25]N>CO>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:23]=[CH:22][C:5]2[C:6]3[NH:25][N:18]=[CH:17][C:7]=3[CH2:8][N:9]=[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 53830000HCID 53830000, compound

Product 1

HCID 21431643HCID 21431643, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The mixture of 1 g of 8-chloro-4-dimethylaminomethylidene-1-phenyl-3,4-dihydro-2-benzazepin-5-one, 0.33 g of hydrazine hydrate and 45 ml of methanol is refluxed for 4 hours and evaporated under reduced pressure. The residue is taken up in the mainimum amount of acetone-ethanol, the solution acidified with ethereal hydrogen chloride and the precipitate formed filtered off, to yield the 8-chloro-6-phenyl-1H,4H-pyrazolo[4,3-d](2 )benzazepine dihydrochloride of the formula ##STR16## melting at 268° - 270°.

Workup

  1. temperatureis refluxed for 4 hours
  2. customevaporated under reduced pressure
  3. customthe precipitate formed
  4. filtrationfiltered off

Sources & evidence

ORD record
ord-9008e31a2e4240cd93b6bf24f22baf00
Source dataset
uspto-grants-1977_05
Patent number
US04022801

Reaction notes

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