1,3-Propanediamine → 2-(3-Aminopropylamino)pyrazine

HRID 2397727Notes

Reaction equation

HRID 2397727 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1.[NH2:8][CH2:9][CH2:10][CH2:11][NH2:12].[O-]CC.[Na+]>C(O)C>[NH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:2]1[CH:7]=[N:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 4281,3-PropanediamineHCID 73277ChloropyrazineHCID 2723922Sodium ethoxide

Product 1

HCID 143974072-(3-Aminopropylamino)pyrazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reacting 2-chloropyrazine with 1,3-diaminopropane in ethanol containing sodium ethoxide by the procedure of Example 89 gives (2-(3-aminopropylamino)-pyrazine.

Sources & evidence

ORD record
ord-59a773248fe14758b5880c38c2da1233
Source dataset
uspto-grants-1977_05
Patent number
US04022797

Reaction notes

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