Propane sultone → 3-((1-Methylcyclopentyl)amino)propane-1-sulfonic acid

HRID 239783Notes

Reaction equation

HRID 239783 reaction equation
[CH2:1]1[CH2:7][S:4](=[O:6])(=[O:5])[O:3][CH2:2]1.[CH3:8][C:9]1([NH2:14])[CH2:13][CH2:12][CH2:11][CH2:10]1>CC(=O)CC>[CH3:8][C:9]1([NH:14][CH2:2][CH2:1][CH2:7][S:4]([OH:3])(=[O:6])=[O:5])[CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 14264Propane sultoneHCID 520998Cyclopentanamine, 1-methyl-

Product 1

HCID 160358473-((1-Methylcyclopentyl)amino)propane-1-sulfonic acid

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A solution of 1,3-propanesultone (9.4 g, 75 mmol) in 2-butanone (35 mL) was added dropwise to a the crude solution of 1-methyl-1-cyclopentylamine (mixture of solvent from previous step).

Sources & evidence

ORD record
ord-66bb6a4238b34d41bba2199ffc7e2a15
Source dataset
uspto-grants-2014_02
Patent number
US08642801B2

Reaction notes

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