Acetic Anhydride → HCID 21436690, compound

HRID 2397841Notes

Reaction equation

HRID 2397841 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[C:3]=1[N+:9]([O-:11])=[O:10].[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([NH:8][C:4]1[C:3]([N+:9]([O-:11])=[O:10])=[C:2]([Cl:1])[CH:7]=[CH:6][N:5]=1)(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 40716944-Chloro-3-nitropyridin-2-amine

Product 1

HCID 21436690HCID 21436690, compound

Procedure

When 10.0 g. of 4-chloro-2-amino-3-nitropyridine, from Example I-5, and 20 ml of acetic anhydride are heated under reflux for 1 hour and then concentrated, there is obtained 2-acetamido-4-chloro-3-nitropyridine, and, this, heated at 300° C. and treated with chlorine gives 2-acetamido-4,5-dichloro-3-nitropyridine. The latter by the procedure of Example I-2 gives 2-amino-4,5-dichloro-3-pyridinol.

Workup

  1. temperatureunder reflux for 1 hour
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-bfdc0f89e37545c7bfd516aaa44c0a3a
Source dataset
uspto-grants-1977_05
Patent number
US04022897

Reaction notes

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