Acetic Anhydride → HCID 21436690, compound

Participants

Reaction Steps

When 10.0 g. of 4-chloro-2-amino-3-nitropyridine, from Example I-5, and 20 ml of acetic anhydride are heated under reflux for 1 hour and then concentrated, there is obtained 2-acetamido-4-chloro-3-nitropyridine, and, this, heated at 300° C. and treated with chlorine gives 2-acetamido-4,5-dichloro-3-nitropyridine. The latter by the procedure of Example I-2 gives 2-amino-4,5-dichloro-3-pyridinol.

Provenance & Evidence