Bromine → 2-Amino-5-bromo-3-hydroxypyridine

HRID 2397849Notes

Reaction equation

HRID 2397849 reaction equation
[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[Br:9]Br>C(O)C>[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([Br:9])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 281142-Amino-3-Hydroxypyridine

Product 1

HCID 116940412-Amino-5-bromo-3-hydroxypyridine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
5 °C

Procedure

The 2-amino-5-bromo-3-pyridinol is prepared by dissolving 110.0 g of 2-amino-3-pyridinol in 250 ml of 95% ethanol. The solution is cooled to about 5° C. and at that temperature is treated with 160 g of liquid bromine during 2 hours. The mixture is stirred for 1 hour after the addition is completed and then concentrated to give 170.6 g of 2-amino-5-bromo-3-pyridinol.

Workup

  1. customThe 2-amino-5-bromo-3-pyridinol is prepared
  2. additionafter the addition
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-2ba2765ecc9743288bc32ffbcbbf357a
Source dataset
uspto-grants-1977_05
Patent number
US04022897

Reaction notes

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