2-Bromobenzyl bromide → HCID 12369843, compound

HRID 2397851Notes

Reaction equation

HRID 2397851 reaction equation
[OH:1][C:2]1[C:7]2=[N:8][C:9]([CH3:13])=[CH:10][C:11](=[O:12])[N:6]2[CH:5]=[CH:4][CH:3]=1.C[O-].[Na+].[Br:17][C:18]1[CH:25]=[CH:24][CH:23]=[CH:22][C:19]=1[CH2:20]Br>C(O)C>[Br:17][C:18]1[CH:25]=[CH:24][CH:23]=[CH:22][C:19]=1[CH2:20][O:1][C:2]1[C:7]2=[N:8][C:9]([CH3:13])=[CH:10][C:11](=[O:12])[N:6]2[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 769652-Bromobenzyl bromideHCID 796646HCID 796646, compoundHCID 10942334Sodium Methoxide

Product 1

HCID 12369843HCID 12369843, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent3×

Procedure

To 35.2 g of 9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one suspended in 100 ml of absolute ethanol is added a solution of 11.0 g of sodium methoxide in 165 ml of absolute ethanol. To this is then added 50.0 g o-bromobenzyl bromide dissolved in 25 ml of absolute ethanol. The mixture is then heated under reflux for about 6 hours and worked up to give 9-[(o-bromobenzyl)oxy]-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one, m.p. 144°-146°, after recrystallization from ethyl acetate.

Workup

  1. temperatureThe mixture is then heated
  2. temperatureunder reflux for about 6 hours

Sources & evidence

ORD record
ord-cd06eb40195442ed87f1f0fde81f06f2
Source dataset
uspto-grants-1977_05
Patent number
US04022897

Reaction notes

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