2-Bromobenzyl bromide → HCID 12369843, compound

Participants

Reaction Steps

To 35.2 g of 9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one suspended in 100 ml of absolute ethanol is added a solution of 11.0 g of sodium methoxide in 165 ml of absolute ethanol. To this is then added 50.0 g o-bromobenzyl bromide dissolved in 25 ml of absolute ethanol. The mixture is then heated under reflux for about 6 hours and worked up to give 9-[(o-bromobenzyl)oxy]-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one, m.p. 144°-146°, after recrystallization from ethyl acetate.

Provenance & Evidence