Potassium Iodide → HCID 56636445, compound

HRID 2397855Notes

Reaction equation

HRID 2397855 reaction equation
[OH-].[K+].[I-].[K+].[OH:5][C:6]1[C:11]2=[N:12][C:13]([CH3:17])=[CH:14][C:15](=[O:16])[N:10]2[CH:9]=[CH:8][C:7]=1[CH3:18].[CH2:19](Br)[CH:20]=[CH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>O.CO>[CH2:19]([O:5][C:6]1[C:11]2=[N:12][C:13]([CH3:17])=[CH:14][C:15](=[O:16])[N:10]2[CH:9]=[CH:8][C:7]=1[CH3:18])[CH:20]=[CH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 14797Potassium HydroxideHCID 98116BromomethylstyreneHCID 21436684HCID 21436684, compound

Product 1

HCID 56636445HCID 56636445, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent

Procedure

To a solution of 6.6 g of potassium hydroxide (85%) and 0.2 g of potassium iodide in 100 ml of water is added 150 ml of methanol and 19.0 g of 9-hydroxy-2,8-dimethyl-4H-pyrido[ 1,2-a]-pyrimidin-4-one and the whole stirred for about 1 hour. To this is added 20.1 g of cinnamyl bromide dissolved in 20 ml of methanol. The mixture is stirred at room temperature for about 18 hours and then worked up to give 9-[ (cinnamyl)oxy] -2,8-dimethyl-4H-pyrido[ 1,2-a] pyrimidin-4-one.

Workup

  1. stirringThe mixture is stirred at room temperature for about 18 hours

Sources & evidence

ORD record
ord-b93ac49ca99f4e77ae8857018fc64b78
Source dataset
uspto-grants-1977_05
Patent number
US04022897

Reaction notes

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