Bromine → 2-Bromo-6-methoxy-3-phenylbenzofuran

HRID 2397879Notes

Reaction equation

HRID 2397879 reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]2[C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:8][O:9][C:5]=2[CH:4]=1.[Br:18]Br>ClCCl>[Br:18][C:8]1[O:9][C:5]2[CH:4]=[C:3]([O:2][CH3:1])[CH:17]=[CH:16][C:6]=2[C:7]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 51727006-Methoxy-3-phenyl-benzofuran

Product 1

HCID 214367902-Bromo-6-methoxy-3-phenylbenzofuran

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 25 g (0.112 mole) of 6-methoxy-3 -phenylbenzofuran in 400 ml of dichloromethane is added over 1 hour dropwise with stirring 17.9 g (0.112 mole) of bromine in 20 ml of dichloromethane. The solution is washed with 200 ml of 10% aqueous sodium acetate, dried and evaporated to provide 2-bromo-6-methoxy-3-phenylbenzofuran as a dark oil.

Workup

  1. washThe solution is washed with 200 ml of 10% aqueous sodium acetate
  2. customdried
  3. customevaporated

Sources & evidence

ORD record
ord-49598e2dd0bc4a4ea305df3d36a9826d
Source dataset
uspto-grants-1977_05
Patent number
US04022908

Reaction notes

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