HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-Amino-6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Amidinoacetic acid isopropyl ester | HCID 12391080 | — |
| Reactant | Methyl 5-(2-nitrophenyl)-3-oxopent-4-enoate | HCID 53723829 | — |
| Product | 2-Amino-6-methyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-methyl ester | HCID 70635723 | 50% |
Reaction Steps
Upon heating a solution of 12.5 g of 2-nitrobenzylideneacetoacetic acid methyl ester and 7.2 g of amidinoacetic acid isopropyl ester in 100 ml of ethanol for 8 hours, 2-amino-6-methyl-4-(2 -nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-methyl ester of melting point 203° C. (isopropanol) is obtained. Yield: 50% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04022898 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-516b89b9474648d79ff59c03bf3b7206 |
| Source note | uspto-grants-1977_05 |