2-Iodobenzoyl chloride → 2-Iodo-N-(2-methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)benzene-1-carboximidic acid

HRID 2397946Notes

Reaction equation

HRID 2397946 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2.[I:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16](Cl)=[O:17]>>[I:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16]([NH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2)=[O:17]

Participants

3

Reactant 2

HCID 691122-Iodobenzoyl chlorideHCID 141712692-Methyl-1,2,3,4-tetrahydroisoquinolin-5-amine

Product 1

HCID 2166002-Iodo-N-(2-methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)benzene-1-carboximidic acid

Procedure

5-Amino-2-methyl-1,2,3,4-tetrahydroisoquinoline was reacted with 2-iodobenzoyl chloride according to the procedure of Example 19 to yield 5-(2-iodobenzamido)-2-methyl-1,2,3,4-tetrahydroisoquinoline; m.p. 215°-216.5° C. after purification from methanol.

Sources & evidence

ORD record
ord-cbfa98e359de46aaa9e593f3a0295317
Source dataset
uspto-grants-1977_05
Patent number
US04022900

Reaction notes

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