19-Hydroxyandrostenedione → 4-Androstene-3beta,17beta,19-triol

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Reaction Steps

The 3,17-dihydroxy-4-androsten-19-ones and the diether derivatives are available from the corresponding 19-hydroxy-4-androstene-3,17-dione acylates. Reduction of these compounds with lithium tri-t-butoxyaluminum hydride reduces the 3 and 17-ketones to the β-alcohols without loss of the 19-acylate to furnish 4-androstene-3β,17β,19-triol 19-acylate.

Provenance & Evidence