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HRID2397981

反应详情

EQUATION

反应方程式

HRID 2397981 的结构方程式

REACTANTS

反应物

3
结构：c1ccncc1
HCID1049

Pyridine

C5H5N

结构：C[Si](C)(C)Cl
HCID6397

Chlorotrimethylsilane

C3H9ClSi

结构：C[C@H]1CCC=C2CC[C@H]3[C@@H]4CC[C@H](O)[C@@]4(C)CC[C@@H]3[C@]21C=O
HCID86734736

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1CCC=C2CC[C@H]3[C@@H]4CC[C@H](O[Si](C)(C)C)[C@@]4(C)CC[C@@H]3[C@]21C=O
HCID22797462

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccccc1
溶剂HCID241

Benzene

C6H6

PROCEDURE

实验过程

A mixture of 17β-hydroxy-1α-methyl-4-androsten-19-one, trimethylchlorosilane and pyridine is refluxed in benzene for a period of about 18 hours. The suspension is filtered and the benzene removed under vacuum. The resulting oil is eluted from a silica gel chromatograph with benzene and crystallized from hexane to yield 1α-methyl-17β-trimethylsiloxy-4-androsten-19-one.

WORKUP

后处理

  1. filtrationThe suspension is filtered
  2. customthe benzene removed under vacuum
  3. washThe resulting oil is eluted from a silica gel chromatograph with benzene
  4. customcrystallized from hexane