HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 1alpha-Methyl-17beta-trimethylsiloxy-4-androsten-19-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 17beta-Hydroxy-1alpha-methyl-4-androsten-19-one | HCID 86734736 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1alpha-Methyl-17beta-trimethylsiloxy-4-androsten-19-one | HCID 22797462 | — |
Reaction Steps
A mixture of 17β-hydroxy-1α-methyl-4-androsten-19-one, trimethylchlorosilane and pyridine is refluxed in benzene for a period of about 18 hours. The suspension is filtered and the benzene removed under vacuum. The resulting oil is eluted from a silica gel chromatograph with benzene and crystallized from hexane to yield 1α-methyl-17β-trimethylsiloxy-4-androsten-19-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04022769 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-48c98a8e1e484003ad2460da471f252f |
| Source note | uspto-grants-1977_05 |