反应详情

A tetrahydrofuran solution of 1β-methyl-5-androstene-3,17-dione so prepared is added under nitrogen to a solution of lithium tri-t-butoxyaluminum hydride in tetrahydrofuran. After stirring at room temperature for about 18 hours, an aqueous solution of potassium sodium tartrate is added with stirring to form a readily filterable white solid. The reaction mixture is filtered, the filtrate dried over magnesium sulfate, and the solvent removed from the filtrate. The residue which is crystallized from acetone-hexane yields 1β-methyl-5-androstene-3β,17β-diol.

1. stirringwith stirring
2. customto form a readily filterable white solid
3. filtrationThe reaction mixture is filtered
4. dry with materialthe filtrate dried over magnesium sulfate
5. customthe solvent removed from the filtrate
6. customThe residue which is crystallized from acetone-hexane