Hydrochloric Acid → n-Butyl 1-aminomethyl-1-cyclohexane acetate hydrochloride

HRID 2398122Notes

Reaction equation

HRID 2398122 reaction equation
[ClH:1].[NH2:2][CH2:3][C:4]1([CH2:10][C:11]([OH:13])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1.Cl>C(O)CCC>[ClH:1].[NH2:2][CH2:3][C:4]1([CH2:10][C:11]([O:13][CH2:3][CH2:4][CH2:5][CH3:6])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 6453919Gabapentin hydrochloride

Product 1

HCID 85899869n-Butyl 1-aminomethyl-1-cyclohexane acetate hydrochloride

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A solution of 1aminomethyl-1-cyclohexane-acetic acid hydrochloride in n-butanol is saturated with hydrogen chloride at 0° C. The reaction mixture is then heated to 110° C for 2 hours while hydrogen chloride is passed through. The solution thus obtained is then evaporated at 60° C and the residue stirred up with hexane is filtered and dried. n-Butyl 1-aminomethyl-1-cyclohexane acetate hydrochloride is obtained in form of a white powder having a melting point of 106°-109° C.

Workup

  1. customThe solution thus obtained
  2. customis then evaporated at 60° C
  3. filtrationis filtered
  4. customdried

Sources & evidence

ORD record
ord-ab26532c734d4bbdbc4a5cbee17ee81f
Source dataset
uspto-grants-1977_05
Patent number
US04024175

Reaction notes

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