Cyclohexyl isocyanate → HCID 21434460, compound

HRID 2398163Notes

Reaction equation

[CH2:1]([N:5]([CH2:23][CH2:24][CH2:25][CH3:26])[C:6]([N:8]1[CH2:14][CH2:13][C:12]2[CH:15]=[CH:16][C:17]([S:19]([NH2:22])(=[O:21])=[O:20])=[CH:18][C:11]=2[CH2:10][CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4].[CH:27]1([N:33]=[C:34]=[O:35])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1>>[CH:27]1([NH:33][C:34]([NH:22][S:19]([C:17]2[CH:16]=[CH:15][C:12]3[CH2:13][CH2:14][N:8]([C:6](=[O:7])[N:5]([CH2:23][CH2:24][CH2:25][CH3:26])[CH2:1][CH2:2][CH2:3][CH3:4])[CH2:9][CH2:10][C:11]=3[CH:18]=2)(=[O:21])=[O:20])=[O:35])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

Participants

Reactant 2

HCID 18502Cyclohexyl isocyanate

HCID 21434463HCID 21434463, compound

Product 1

HCID 21434460HCID 21434460, compound

Procedure

In a manner analogous to that described in Example 1, from 3-dibutylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide and cyclohexylisocyanate, there is obtained 1-cyclohexyl-3-[(3-dibutylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)sulfonyl]urea, m.p. 118°-120° C. The starting material can be prepared by the reaction of 2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide hydrochloride with dibutylcarbamoyl chloride in a manner analogous to that described in Example 1.

Sources & evidence

ORD record: ord-468025139a614e07af28de3353016840
Source dataset: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04024128

Reaction notes

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