反应详情

3.4 G. of 2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide are dissolved in 50 ml. of dimethylformamide while warming at 60° C. and the solution is then rapidly cooled with an icebath. As soon as a temperature of 20° C. is reached, 1.18 ml. of ethylisocyanate are added dropwise while stirring, and the mixture is subsequently stirred at 25° C. for 0.5 hour. The solution is then concentrated in vacuo on a bath at 80° C. and the crystalline residue is digested with ether. There is obtained 3-ethylcarbamoyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-sulfonamide.

1. temperaturethe solution is then rapidly cooled with an icebath
2. customsoon as a temperature of 20° C.
3. stirringthe mixture is subsequently stirred at 25° C. for 0.5 hour
4. concentrationThe solution is then concentrated in vacuo on a bath at 80° C.